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1 oleoyl n heptadecanoyl d erythro sphingosine  (Avanti Polar)


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    Avanti Polar 1 oleoyl n heptadecanoyl d erythro sphingosine
    1 Oleoyl N Heptadecanoyl D Erythro Sphingosine, supplied by Avanti Polar, used in various techniques. Bioz Stars score: 90/100, based on 8 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/1 oleoyl n heptadecanoyl d erythro sphingosine/product/Avanti Polar
    Average 90 stars, based on 8 article reviews
    1 oleoyl n heptadecanoyl d erythro sphingosine - by Bioz Stars, 2026-02
    90/100 stars

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    Effect of tamoxifen treatment on L. amazonensis sphingolipid biosynthesis. Metabolic labeling of 1 × 10 8 L. amazonensis promastigotes with 6 μCi of [ <t>3</t> <t>H]-sphingosine</t> (lanes 2 and 3) or 6 μCi of [ 3 H]-inositol (lanes 5 and 6). Parasites were treated with 10 μM tamoxifen for 4 h and purified total lipids were analyzed by HPTLC using running system 1. ST(S): [ 3 H]-sphingosine standard without incubation with cells, ST(I): [ 3 H]-inositol standard without incubation with cells, Sph*: lipid extract of [ 3 H]-sphingosine labeled parasites, Ino*: lipid extract of [ 3 H]-inositol labeled parasites, Ct: lipid extract of untreated parasites, Tam: lipid extract of parasites treated with tamoxifen, C16-cer: <t>C16-ceramide</t> standard, PI 18:1: phosphatidylinositol 18:1 standard, O: origin, F: front.
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    Effect of tamoxifen treatment on L. amazonensis sphingolipid biosynthesis. Metabolic labeling of 1 × 10 8 L. amazonensis promastigotes with 6 μCi of [ <t>3</t> <t>H]-sphingosine</t> (lanes 2 and 3) or 6 μCi of [ 3 H]-inositol (lanes 5 and 6). Parasites were treated with 10 μM tamoxifen for 4 h and purified total lipids were analyzed by HPTLC using running system 1. ST(S): [ 3 H]-sphingosine standard without incubation with cells, ST(I): [ 3 H]-inositol standard without incubation with cells, Sph*: lipid extract of [ 3 H]-sphingosine labeled parasites, Ino*: lipid extract of [ 3 H]-inositol labeled parasites, Ct: lipid extract of untreated parasites, Tam: lipid extract of parasites treated with tamoxifen, C16-cer: <t>C16-ceramide</t> standard, PI 18:1: phosphatidylinositol 18:1 standard, O: origin, F: front.
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    Effect of tamoxifen treatment on L. amazonensis sphingolipid biosynthesis. Metabolic labeling of 1 × 10 8 L. amazonensis promastigotes with 6 μCi of [ <t>3</t> <t>H]-sphingosine</t> (lanes 2 and 3) or 6 μCi of [ 3 H]-inositol (lanes 5 and 6). Parasites were treated with 10 μM tamoxifen for 4 h and purified total lipids were analyzed by HPTLC using running system 1. ST(S): [ 3 H]-sphingosine standard without incubation with cells, ST(I): [ 3 H]-inositol standard without incubation with cells, Sph*: lipid extract of [ 3 H]-sphingosine labeled parasites, Ino*: lipid extract of [ 3 H]-inositol labeled parasites, Ct: lipid extract of untreated parasites, Tam: lipid extract of parasites treated with tamoxifen, C16-cer: <t>C16-ceramide</t> standard, PI 18:1: phosphatidylinositol 18:1 standard, O: origin, F: front.
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    Effect of tamoxifen treatment on L. amazonensis sphingolipid biosynthesis. Metabolic labeling of 1 × 10 8 L. amazonensis promastigotes with 6 μCi of [ 3 H]-sphingosine (lanes 2 and 3) or 6 μCi of [ 3 H]-inositol (lanes 5 and 6). Parasites were treated with 10 μM tamoxifen for 4 h and purified total lipids were analyzed by HPTLC using running system 1. ST(S): [ 3 H]-sphingosine standard without incubation with cells, ST(I): [ 3 H]-inositol standard without incubation with cells, Sph*: lipid extract of [ 3 H]-sphingosine labeled parasites, Ino*: lipid extract of [ 3 H]-inositol labeled parasites, Ct: lipid extract of untreated parasites, Tam: lipid extract of parasites treated with tamoxifen, C16-cer: C16-ceramide standard, PI 18:1: phosphatidylinositol 18:1 standard, O: origin, F: front.

    Journal: International Journal for Parasitology: Drugs and Drug Resistance

    Article Title: Tamoxifen inhibits the biosynthesis of inositolphosphorylceramide in Leishmania

    doi: 10.1016/j.ijpddr.2018.10.007

    Figure Lengend Snippet: Effect of tamoxifen treatment on L. amazonensis sphingolipid biosynthesis. Metabolic labeling of 1 × 10 8 L. amazonensis promastigotes with 6 μCi of [ 3 H]-sphingosine (lanes 2 and 3) or 6 μCi of [ 3 H]-inositol (lanes 5 and 6). Parasites were treated with 10 μM tamoxifen for 4 h and purified total lipids were analyzed by HPTLC using running system 1. ST(S): [ 3 H]-sphingosine standard without incubation with cells, ST(I): [ 3 H]-inositol standard without incubation with cells, Sph*: lipid extract of [ 3 H]-sphingosine labeled parasites, Ino*: lipid extract of [ 3 H]-inositol labeled parasites, Ct: lipid extract of untreated parasites, Tam: lipid extract of parasites treated with tamoxifen, C16-cer: C16-ceramide standard, PI 18:1: phosphatidylinositol 18:1 standard, O: origin, F: front.

    Article Snippet: Subsequent dilutions were done in culture media. d18:1/16:0 C16-ceramide (N-palmitoyl-D- erythro -sphingosine, Avanti ® Polar Lipids, Inc.), 18:1 PI [1,2-dioleoyl- sn -glycero-3-phosphoinositol (ammonium salt), Avanti ® Polar Lipids, Inc.] and acyl-ceramide (1-oleoyl-N-heptadecanoyl-D-erythro-sphingosine, Avanti ® Polar Lipids, Inc.) were used as standards.

    Techniques: Labeling, Purification, High Performance Thin Layer Chromatography, Incubation

    Lipid D characterization by alkaline hydrolysis. (A) Acyl ceramide structure. (B) Total lipid extracts from lipid D fractions of [ 3 H]-sphingosine metabolic labeled L. amazonensis promastigotes treated or not with 10 μM tamoxifen were incubated in 100 mM NaOH (lane 3 and 4) or NaCl (lane 1 and 2) in 95% methanol aqueous solution for 1 h. Total lipid extracts from 3 × 10 8 cells were applied to each lane and analyzed by HPTLC using running system 2. D: lipid D, Acyl-cer: Acyl-ceramide standard, C16-cer: C16-ceramide standard, Ct: lipid extract of untreated parasites, Tam: lipid extract of parasites treated with tamoxifen, NaCl: extract incubated with 100 mM NaCl, NaOH: extract incubated with 100 mM NaOH, O: origin, F: front.

    Journal: International Journal for Parasitology: Drugs and Drug Resistance

    Article Title: Tamoxifen inhibits the biosynthesis of inositolphosphorylceramide in Leishmania

    doi: 10.1016/j.ijpddr.2018.10.007

    Figure Lengend Snippet: Lipid D characterization by alkaline hydrolysis. (A) Acyl ceramide structure. (B) Total lipid extracts from lipid D fractions of [ 3 H]-sphingosine metabolic labeled L. amazonensis promastigotes treated or not with 10 μM tamoxifen were incubated in 100 mM NaOH (lane 3 and 4) or NaCl (lane 1 and 2) in 95% methanol aqueous solution for 1 h. Total lipid extracts from 3 × 10 8 cells were applied to each lane and analyzed by HPTLC using running system 2. D: lipid D, Acyl-cer: Acyl-ceramide standard, C16-cer: C16-ceramide standard, Ct: lipid extract of untreated parasites, Tam: lipid extract of parasites treated with tamoxifen, NaCl: extract incubated with 100 mM NaCl, NaOH: extract incubated with 100 mM NaOH, O: origin, F: front.

    Article Snippet: Subsequent dilutions were done in culture media. d18:1/16:0 C16-ceramide (N-palmitoyl-D- erythro -sphingosine, Avanti ® Polar Lipids, Inc.), 18:1 PI [1,2-dioleoyl- sn -glycero-3-phosphoinositol (ammonium salt), Avanti ® Polar Lipids, Inc.] and acyl-ceramide (1-oleoyl-N-heptadecanoyl-D-erythro-sphingosine, Avanti ® Polar Lipids, Inc.) were used as standards.

    Techniques: Labeling, Incubation, High Performance Thin Layer Chromatography

    Schematic diagram summarizing potential tamoxifen targets related to sphingolipid biosynthesis in Leishmania . Reduced IPC levels (blue arrows) in L. amazonensis promastigotes treated with tamoxifen are related to IPC synthase inhibition (red bars). Reduced PI and IPC intracellular levels (blue arrows) could also be related to reduced incorporation of inositol into the cell or to direct or indirect inhibition of PI and/or IPC synthase (purple bars). The increased levels of acylated ceramide may be a result from intracellular ceramide accumulation (green arrow) due to its reduced use as a source for IPC synthesis. Labeled PI observed in [ 3 H]-Sphingosine-labeled parasites may be generated by hexadecenal pathway from sphingosine-1-phosphate degradation. DAG: diacylglycerol; CDP-DAG: cytidine diphosphate diacylglycerol; PIS: phosphatidylinositol synthase; IPC: inositolphophorylceramide; EtN-P: phosphoetalonamine; Alkyl-G3P: 1-alkylglycerol-3-phosphate; CDase: ceramidase; CDP-DAG: cytidine diphosphate diacylglycerol; CerS: ceramide synthase; DAG: diacylglycerol; EtN-P: phosphoetalonamine; IPC: inositolphophorylceramide; IPCS: inositolphosphorylceramide synthase; ISCL: inositolsphingolipid phospholipase C-like; PI: phosphatidylinositol; PIS: phosphatidylinositol synthase; S1PL: sphingosine-1-phosphate lyase; Sph-1-P: sphingosine-1-phosphate; TAM: tamoxifen. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

    Journal: International Journal for Parasitology: Drugs and Drug Resistance

    Article Title: Tamoxifen inhibits the biosynthesis of inositolphosphorylceramide in Leishmania

    doi: 10.1016/j.ijpddr.2018.10.007

    Figure Lengend Snippet: Schematic diagram summarizing potential tamoxifen targets related to sphingolipid biosynthesis in Leishmania . Reduced IPC levels (blue arrows) in L. amazonensis promastigotes treated with tamoxifen are related to IPC synthase inhibition (red bars). Reduced PI and IPC intracellular levels (blue arrows) could also be related to reduced incorporation of inositol into the cell or to direct or indirect inhibition of PI and/or IPC synthase (purple bars). The increased levels of acylated ceramide may be a result from intracellular ceramide accumulation (green arrow) due to its reduced use as a source for IPC synthesis. Labeled PI observed in [ 3 H]-Sphingosine-labeled parasites may be generated by hexadecenal pathway from sphingosine-1-phosphate degradation. DAG: diacylglycerol; CDP-DAG: cytidine diphosphate diacylglycerol; PIS: phosphatidylinositol synthase; IPC: inositolphophorylceramide; EtN-P: phosphoetalonamine; Alkyl-G3P: 1-alkylglycerol-3-phosphate; CDase: ceramidase; CDP-DAG: cytidine diphosphate diacylglycerol; CerS: ceramide synthase; DAG: diacylglycerol; EtN-P: phosphoetalonamine; IPC: inositolphophorylceramide; IPCS: inositolphosphorylceramide synthase; ISCL: inositolsphingolipid phospholipase C-like; PI: phosphatidylinositol; PIS: phosphatidylinositol synthase; S1PL: sphingosine-1-phosphate lyase; Sph-1-P: sphingosine-1-phosphate; TAM: tamoxifen. (For interpretation of the references to colour in this figure legend, the reader is referred to the Web version of this article.)

    Article Snippet: Subsequent dilutions were done in culture media. d18:1/16:0 C16-ceramide (N-palmitoyl-D- erythro -sphingosine, Avanti ® Polar Lipids, Inc.), 18:1 PI [1,2-dioleoyl- sn -glycero-3-phosphoinositol (ammonium salt), Avanti ® Polar Lipids, Inc.] and acyl-ceramide (1-oleoyl-N-heptadecanoyl-D-erythro-sphingosine, Avanti ® Polar Lipids, Inc.) were used as standards.

    Techniques: Inhibition, Labeling, Generated